Tea consumption and the risk of overall and grade specific prostate cancer

　英國蘇格蘭格拉斯哥大學一項新研究指出，男性若有大量喝茶習慣，罹患攝護腺癌的風險可能更高，但兩者關係與作用機轉尚不清楚。不過，國內醫師表示，罹患攝護腺癌的原因有很多，不會因吃某種特定食物就罹癌，研究參考就好。

    　這項研究稱為「中跨合作研究」（Midspan Collaborative Study），始於一九七○年，調查對象為六千零一十六名男性，年齡在廿一歲至七十五歲之間，他們先被要求填寫問卷回答有關喝茶、喝咖啡或抽菸的量以及整體健康狀況，然後接受篩檢。

    　在長達卅七年的追蹤期間，每天喝逾七杯茶的人，有六．四％罹患攝護腺癌；相較之下，每天頂多喝三杯茶的人，有四．六％罹癌。整體而言，每天喝逾七杯茶的人，與適量喝茶或不喝茶的人相比，罹患攝護腺癌的風險高出五○％。

    　主持研究的夏菲克（Kashif Shafique）博士表示：「我們（的研究）並不能確定茶本身是否為危險因子，或者是受測者因為活到年事更長才較易罹癌。」「攝護腺癌慈善基金會」研究主任荷梅斯（Kate Holmes）博士也指出，這項研究並未考量受測者的家族病史，或者其他飲食習慣。

    　國內醫師也對此研究結果持保留態度。台大醫院泌尿部主治醫師陳忠信表示，罹患攝護腺癌有許多因素，但沒有研究證實茶會使罹患攝護腺癌的機率變高，研究僅供參考。

    　書田診所泌尿科主任洪峻澤表示，黑人攝護腺癌發病率最高，白種人其次，黃種人攝護腺癌發病率最低。近年來「吃什麼罹什麼癌」相關研究報告太多，多只能提供參考，「茶還是可以照樣喝啦！」2012-06-20中國時報王嘉源、張睿纖／綜合報導

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 http://eprints.gla.ac.uk/65682/

Tea consumption and the risk of overall and grade specific prostate cancer: a large prospective cohort study of Scottish men

Shafique, K., McLoone, P. , Qureshi, K., Leung, H. , Hart, C. , and Morrison, D.S. (2012) Tea consumption and the risk of overall and grade specific prostate cancer: a large prospective cohort study of Scottish men. Nutrition and Cancer . ISSN 0163-5581 (doi:10.1080/01635581.2012.690063) (In Press)

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Publisher's URL: http://dx.doi.org/10.1080/01635581.2012.690063

Abstract

Tea may be a potentially modifiable and highly prevalent risk factor for the most common cancer in men, prostate cancer. However, associations between black tea consumption and prostate cancer in epidemiological studies have been inconsistent, limited to a small number of studies with small numbers of cases and short follow-up periods and without grade-specific information. We conducted a prospective cohort study of 6,016 men who were enrolled in the Collaborative Cohort Study between 1970 and 1973 and followed up to December 31, 2007. We used Cox proportional hazards models to investigate the association between tea consumption and overall as well as grade-specific risk of prostate cancer incidence. Three hundred and eighteen men developed prostate cancer in up to 37 years of follow-up. We found a positive association between consumption of tea and overall risk of prostate cancer incidence (P = 0.02). The association was greatest among men who drank ≥7 cups of tea per day (HR: 1.50, 95% CI: 1.06 to 2.12), compared with the baseline of 0–3 cups/day. However, we did not find any significant association between tea intake and low- (Gleason <7) or high-grade (Gleason 8–10) prostate cancer incidence. Men with higher intake of tea are at greater risk of developing prostate cancer, but there is no association with more aggressive disease. Further research is needed to determine the underlying biological mechanisms for the associat

Item Type:	Article
Status:	In Press
Refereed:	Yes
Glasgow Author(s):	Hart, Dr Carole and McLoone, Mr Philip and Leung, Prof Hing and Morrison, Dr David
Authors:	Shafique, K., McLoone, P. , Qureshi, K., Leung, H. , Hart, C. , and Morrison, D.S.
College/School:	College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > General Practice and Primary Care College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
Journal Name:	Nutrition and Cancer
ISSN:	0163-5581
Published Online:	14 June 2012

The Collaborative Study

The Collaborative Study is an occupational cohort study of 6022 men and 1006 women of working age recruited from 27 workplaces throughout the central belt of Scotland. It took place between 1970 and 1973. The primary multiple health examination consisted of a self-administered questionnaire and a 20 minute attendance for screening at a temporary centre for a height and weight check, respiratory function test, 6 lead ECG, blood pressure, chest x-ray, and 10 ml. fasting blood plasma sample for cholesterol, triglycerides and the phenotyping of lipoproteins. The questionnaire differed from that used in the MAIN study as it included more detailed questions on lifestyle and early life.
In 1977 the workplaces were revisited and participants requested to attend for a second time. About 50% did so. All the information collected has been recorded anonymously on computer and is used extensively for epidemiological analysis. Notification of death is received from the office of the General Registrar for Scotland.
In 1996 permission was granted to allow the linkage with hospital admission data and cancer incidence thus extensively increasing the power of the study as a research tool.